Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

We hypothesized that poorly controlled diabetic status may be a negative prognostic factor for acute mediastinitis of odontogenic origin and we conducted a cohort study in order to verify this hypothesis.

To evaluate the efficacy of topical tacrolimus offered on a custom tray to treat desquamative gingivitis (DG). Study design: Eighteen patients with symptomatic DG related to oral lichen planus (OLP) or mucous membrane pemphigoid (MMP) were selected, of which 13 completed the study. Periodontal treatment was followed by the fabrication of a custom silicone tray to apply a tacrolimus gel formulation (0.1%). Clinical evaluation (complaint of pain and burning – visual analog scale from 0 to 10; and the presence of erythema, desquamation, vesicle/blister, erosion, ulcer, and bleeding) was performed by the same examiner on day one, and every 15 days for 90 days.

We compared effective dose (E) and equivalent thyroid dose of 2 extraoral bitewing (EOBW) units and compared E to their respective panoramic (PAN) modes and to intraoral bitewing radiography (IOBW).

To assess the effects of 3 disinfection protocols on the quality of images acquired with a photostimulable phosphor (PSP) plate system.

A 67-year-old male patient presented with an ulcerated lesion of the left maxillary mucosa adjacent to the first and second molar teeth, which had appeared six weeks previously (Figure 1). Ulceration was present on both the palatal and buccal gingivae. No other significant intra-oral findings were present. Extra-oral examination revealed no apparent lymph node abnormality. The patient was receiving methotrexate 15mg per week for treatment of polyarthritis for five years; no other contributory medical history was present.

A 53-year-old Caucasian woman was referred for evaluation of a nodule on dorsum of tongue with one week of evolution, which appeared after the patient burned her tongue. The medical history was remarkable for breast cancer diagnosed 4 years ago, treated with surgery and chemotherapy. The patient reported to be smoker and occasionally drink alcohol. Clinically, the nodule was asymptomatic, well-delimited, covered by normal mucosa, firm on palpation, and measured approximately 2.0 cm (Figures 1A and B).

Histological evidence of perineural invasion (PNI) is a well-known poor prognostic factor in patients with oral squamous cell carcinoma (OSCC). Unfortunately, PNI can often be evaluated only in post-operative surgical specimens. Identification of a reliable pre-operative molecular marker for PNI may represent an attractive strategy for surgical management of OSCC patients.This study was performed to evaluate the relationship between podoplanin expression in pre-operative incisional biopsies of OSCC and the presence of PNI in surgical samples.

Over the last few years, the legalization and acceptance of medical marijuana (cannabis) for various health conditions has sparked debates across medical communities and societal settings. Recreational marijuana use in the United States has continued to increase since its legalization by many states. Among the many areas of health care affected by this evolving landscape is the field of outpatient sedation and anesthesia. Providing office-based ambulatory anesthesia care is a central element of the day-to-day practice of oral and maxillofacial surgeons.

Virtual Reality (VR) is a promising non-pharmacological tool to manage anxiety in healthcare.

Confusion between CD1a positive non-calcifying calcifying epithelial odontogenic tumors (NCLC-CEOT) and CD1a positive amyloid-rich central odontogenic fibroma (AR-COdF) has become a discussion in the literature recently and reports vary about the frequency of CD1a positivity in both entities. This has led to the growing consensus that CD1a positive staining in non-calcifying amyloid positive lesions confirms the diagnosis of AR-COdF. Here we assess the validity of that notion.

Oral plasma cell mucositis (PCM) or the localized plasma cell gingivitis (PCG) is an idiopathic inflammatory condition often associated with hypersensitivity reactions. This study aimed to evaluate the frequency and features of PCM/PCG in a large biopsy service over a time period of over 20 years.

This study aimed to leverage an artificial intelligence deep learning convolutional neural network (DL CNN) image segmentation approach to detect calcified carotid artery atheromas (CCAAs) on cone beam computed tomography (CBCT) images.

We aimed to examine changes in the mandibular angle, ramus, and condylar neck caused by bruxism and Botulinum Toxin-A (BTX-A) injection to the masseter muscle as calculated with fractal analysis (FA) on panoramic radiographs.

We examined the range, nature, and extent of research conducted regarding the oral and dental implications of hereditary hemorrhagic telangiectasia (HHT) to identify gaps in the research and knowledge of the field.

To evaluate artifact expression in a root adjacent to a dental implant located in the endomass or exomass in cone beam computed tomography (CBCT).

Circular RNAs (circRNAs) regulate biological processes in various human tumors, such as oral squamous cell carcinoma (OSCC). Our study aimed to understand the regulatory function of circ_0049396 in OSCC development.

Objective: This study aimed to evaluate cytology diagnosis accuracy using adjuvant methods in clinical routine for oral cancer. Methods: This prospective study was conducted on 98 patients with clinically potentially malignant or malignant lesions of oral cavity. One oral lesion smear was taken from each patient using a cytobrush before biopsy and stored at PreservCyt® Thinprep. Samples were cytologically analyzed and at the same slide DNA ploidy measurement was performed. The diagnostic methods accuracy was then calculated.

Contemporary studies have identified recurrent rearrangements of EWSR1 or FUS with NFATC2 in extragnathic simple bone cysts (SBCs). We sought to investigate the presence of EWSR1 or FUS rearrangements and the immunophenotypic expression of NKX2.2 and CD99 in a series of SBCs of the jaw.

To evaluate the prognostic value of three histopathological grading systems in cases of lower lip (LLSCC) and oral tongue (OTSCC) squamous cell carcinoma.

Intraoral salivary lymphoepithelial carcinoma (ISLEC) represents an uncommon malignancy with vastly understudied PD-L1 expression levels. Here, we present the clinicopathologic and immunophenotypic characteristics, including PD-L1, in a case series of ISLEC.

The oral leiomyomatous hamartoma (OLH) is uncommon with only 40 cases reported in the English literature. It typically presents early in life as a nodule on the anterior maxillary alveolar tissues or the tongue. The growth potential is limited with few cases reaching dimensions greater than 2.0 cm. The microscopic composition includes an intact surface mucosa with an underlying fibrovascular stroma possessing an unencapsulated proliferation of smooth muscle fascicles. Excision is considered definitive treatment.

The authors identified some unformatted points in the original version of Table 3 (Standard checklist to report a randomized double-blind clinical trial of photobiomodulation for oral mucositis) and present the corrected version below.

The authors regret to inform that in the conclusion of the abstract “Conclusions: The placements of DIs could be considered safe in patients with HNC in sites of alveolar bone that received RT (≤5000 Gy)” the dose information of “(≤5000 Gy)” should read “(≤50 Gy)”, as correctly described in the conclusion of the main manuscript.

A 47-year-old white female with a history significant for thyroid disease presented to a private oral and maxillofacial surgery practice with a mass in the edentulous area of a previously extracted left mandibular first molar (tooth #19). A fixed partial denture was present clinically, with abutments on the mandibular left second molar (#18) and the left mandibular second premolar (#20), and a hygienic pontic replacing the missing tooth. Clinically, the surgeon described the lesion as an asymptomatic 2.0-cm submucosal and palpable mass.

Objectives: Orthognathic surgery is the most frequently published topic in maxillofacial surgery. Systematic reviews are considered the top of the evidence pyramid and are used as a basis for decision-making. This work aims to evaluate whether this type of study is not overly publicized in the case of orthognathic surgery, thereby obscuring existing knowledge.Methods: A review was conducted according to the guidelines of PRISMA and the Leiden Manifesto. GRADE approach was used to assess the level of evidence.

Amyloidosis is a heterogeneous series of diseases associated with extracellular amyloid protein depositions, which can involve multiple organs and tissues, leading to tissue structure alterations and organ dysfunction. The tongue is the most frequently involved site of oral amyloidosis, and one of its characteristic clinical presentations is macroglossia. Here, we report 3 extremely rare cases of amyloidosis exclusively appearing as multiple blood blisters, petechiae, and ecchymoses of the oral mucosa, in the absence of common clinical manifestations of oral and systemic amyloidosis.

Pre- and post-surgical fixed orthodontic appliances are the customary and standard practice for patients that are treatment planned for undergoing orthognathic surgery. Traditionally, most patients undergoing orthognathic surgeries have been in their late teens. While these patients still compose the greatest pool of the orthognathic surgery population, many patients are seeking orthognathic surgery later in life. This older patient population often has different concerns and goals than the younger patient population.

We investigated the correlation between magnetic resonance imaging (MRI) parameters and tumor pathological depth of invasion (pDOI), between pDOI and radiological DOI (rDOI), between rDOI and duration between biopsy and MRI, and between rDOI and duration between MRI and surgery to determine the efficacy of rDOI in identifying small lesions and other conditions.

Now that we have moved beyond the inclination to criticize millennials as indolent and entitled, we are faced with the emergence of Generation Z. Generation Z, the genuine digital natives, are poised to redefine the notion of work-life balance in the workplace once again.

Cervicofacial infections (CFI) are bacterial infections that originate in the upper aerodigestive tract and involve common spaces of the head and neck. The objective of this study is to describe and analyze the epidemiological and clinical variables, treatment and evolution of patients with diagnosis of CFI treated at the Parmenio Piñero Hospital, Argentina.

To explore factors influencing research interest and productivity and perceived barriers to conducting research in Oral Medicine (OM).

Primary intraosseous carcinoma (PIOC) of the jaw is a rare neoplasm which can arise either from the lining epithelium of odontogenic cysts or "de novo" from odontogenic epithelial rests. When the odontogenic cyst is present in the jaws for a long time, the stratified squamous epithelium can become malignant due to chronic inflammation. To be classified as PIOC, the lesion must not have any communication with the surrounding mucosa of the upper aerodigestive tract. Sometimes, it becomes difficult to differentiate PIOC from true carcinoma that originated from the oral mucosa.

The purpose of this study is to identify the immuno-oncologic (IO) signature at the surgical tumor margin (TM) of oral squamous cell carcinoma (OSCC) that is involved in the process of malignant transformation.

The purpose of this article is to review the current uses of virtual reality (VR) and augmented reality (AR) in oral and maxillofacial surgery. We discuss the use of VR/AR in educational training, surgical planning, advances in hardware and software, and the implementation of VR/AR in this field.

Using cone beam computed tomography (CBCT), this study aimed to investigate the radiologic features of cervical vertebral nonsegmentation (CVN) in patients with no known syndromes or pathoses.

The objective of this study was to evaluate 2-dimensional (2D) and 3D morphometric parameters of C-shaped root canals on cone beam computed tomography (CBCT) and microcomputed tomography (microCT) images using nanocomputed tomography (nanoCT) as the reference standard.

We aimed to characterize the histology and the clinicodemographic features of mucoepidermoid carcinoma (MEC), showing continuity with the oral surface mucosa.

The objective of this study was to assess the risk and prevalence of oral cancer in patients with systemic lupus erythematosus (SLE) or discoid lupus erythematosus (DLE).

Lowe syndrome (LS) is a very rare disease (1:500,000) X-linked recessive inheritance that involves the kidneys, eyes, and nervous system. A Mexican 25-year-old male patient presented for diagnosis of multiple radiolucent lesions observed on routine radiographic examination. General aspects revealed cognitive delay, eye alterations and kidney involvement, which support the diagnosis of LS. Radiolucent well-delimited lesions were observed in both mandibular angle and symphysis. Under general anesthesia, incisional biopsy and decompression were performed.

Nodular fasciitis (NF) is a benign myofibroblastic proliferation characterized by rapid growth, a self-limiting course, and USP6 gene rearrangement. Although it can arise in the head and neck region, very few cases of NF involving the sinonasal tract have been reported to date. Herein we report a case of NF involving the nasal cavity presenting as a polypoid well-defined mass causing obstructive symptoms in a male with a history of multiple local surgeries. Although the mass had an unusual clinical presentation, the histopathologic and immunohistochemical findings were consistent with NF.

We aimed to map the correlation between thermoluminescent dosimeters (TLDs) and Gafchromic film for measuring absorbed doses and to compare minimum, maximum, and mean absorbed doses over larger regions of interest and at various craniofacial organs and tissues during cone beam computed tomography (CBCT) exposure of the mandibular third molar region.

Increasing evidence indicates that the immune response plays a critical role in the development of head and neck cancer (HNC). We aimed to develop an immune-related gene signature and evaluate its prognostic value in patients with HNC.

Flap complications continue to be a challenge in microsurgical reconstruction for older adults. We aimed to evaluate the impact of age on surgical outcomes after microvascular reconstruction.

We investigated the efficacy of using diffusion-weighted imaging (DWI) with quantitative apparent diffusion coefficient (ADC) mapping in the diagnosis of maxillary diseases.

This study evaluated changes in image quality and the presence and size of artifacts on radiographs obtained with photostimulable phosphor (PSP) plates after disinfection with 70% ethyl alcohol and 70% isopropyl alcohol.

We evaluated the effect of mandibular asymmetry on the trabecular structure of the mandible as measured through fractal analysis (FA).